The effects of tidal volume size and driving pressure levels on pulmonary complement activation: an observational study in critically ill patients.

ABSTRACT:

Background

Mechanical ventilation can induce or even worsen lung injury, at least in part via overdistension caused by too large volumes or too high pressures. The complement system has been suggested to play a causative role in ventilator-induced lung injury.

Aims and methods

This was a single-center prospective study investigating associations between pulmonary levels of complement activation products and two ventilator settings, tidal volume (V_T) and driving pressure (ΔP), in critically ill patients under invasive ventilation. A miniature bronchoalveolar lavage (BAL) was performed for determination of pulmonary levels of C5a, C3b/c, and C4b/c. The primary endpoint was the correlation between BAL fluid (BALF) levels of C5a and V_T and ΔP. Levels of com

SUBMITTER: de Beer FM 

PROVIDER: S-EPMC7746430 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature