Vitamin D in Type 2 Diabetes: Genetic Susceptibility and the Response to Supplementation.

ABSTRACT: Variants of vitamin D metabolism-genes may predispose to type 2 diabetes (T2D). This study investigated the impact of these variants on disease susceptibility, Vitamin D, parathyroid hormone, C-peptide and HbA1c levels before and after cholecalciferol supplementation in patients with T2D.Twelve polymorphisms within CYP2R1, CYP27B1, DBP, VDR and CYP24A1 were genotyped in 553 T2D patients and 916 controls. In addition 65 patients receiving either cholecalciferol or placebo were analyzed during 6 months intervention and 6 months follow-up.T2D risk alleles are VDR rs7975232 "G" (p_c=0.031), rs1544410 "G" (p_c=0.027) and CYP2R1 rs10741657 "A" (p_c=0.016). Patients with genotypes CYP27B1 rs10877012 "CC" (p_c=4x10^-5), DBP rs7041 "GG" (p_c

SUBMITTER: Klahold E 

PROVIDER: S-EPMC7746514 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature