Alpha-galactosylceramide enhances mucosal immunity to oral whole-cell cholera vaccines.

ABSTRACT: Cholera is a severe diarrheal disease caused by the bacterium Vibrio cholerae (V. cholerae) that results in 3-4 million cases globally with 100,000-150,000 deaths reported annually. Mostly confined to developing nations, current strategies to control the spread of cholera include the provision of safe drinking water and improved sanitation and hygiene, ideally in conjunction with oral vaccination. However, difficulties associated with the costs and logistics of these strategies have hampered their widespread implementation. Specific challenges pertaining to oral cholera vaccines (OCVs) include a lack of safe and effective adjuvants to further enhance gut immune responses, the complex and costly multicomponent vaccine manufacturing, limitations of conventional liquid formulation and the lac

SUBMITTER: Davitt CJH 

PROVIDER: S-EPMC7746523 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature