Effects of 5% Albumin Plus Saline Versus Saline Alone on Outcomes From Large-Volume Resuscitation in Critically Ill Patients.

ABSTRACT:

Objectives

To compare 5% albumin with 0.9% saline for large-volume resuscitation (> 60 mL/Kg within 24 hr), on mortality and development of acute kidney injury.

Design

Retrospective cohort study.

Setting

Patients admitted to ICUs in 13 hospitals across Western Pennsylvania. We analyzed two independent cohorts, the High-Density Intensive Care databases: High-Density Intensive Care-08 (July 2000 to October 2008, H08) and High-Density Intensive Care-15 (October 2008 to December 2014, H15).

Patients

Total of 18,629 critically ill patients requiring large-volume resuscitation.

Interventions

Five percent of albumin in addition to saline versus 0.9% saline.

Measurements and main results

After excluding patients with acute kidney injury prior to large-vol

SUBMITTER: Gomez H 

PROVIDER: S-EPMC7746571 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature