Cryo-EM structure of the inhibited (10S) form of myosin II.

ABSTRACT: Myosin II is the motor protein that enables muscle cells to contract and nonmuscle cells to move and change shape¹. The molecule has two identical heads attached to an elongated tail, and can exist in two conformations: 10S and 6S, named for their sedimentation coefficients^2,3. The 6S conformation has an extended tail and assembles into polymeric filaments, which pull on actin filaments to generate force and motion. In 10S myosin, the tail is folded into three segments and the heads bend back and interact with each other and the tail^3-7, creating a compact conformation in which ATPase activity, actin activation and filament assembly are all highly inhibited^7,8. This switched-off structure appears to function as a key energy-conserving storage mol

SUBMITTER: Yang S 

PROVIDER: S-EPMC7746622 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature