External Corroboration That Corticosteroids May Be Harmful to Septic Shock Endotype A Patients.

ABSTRACT:

Objectives

We previously reported gene expression-based endotypes of pediatric septic shock, endotypes A and B, and that corticosteroid exposure was independently associated with increased mortality among pediatric endotype A patients. The Vasopressin vs Norepinephrine as Initial Therapy in Septic Shock trial tested the efficacy of vasopressin as initial vasopressor therapy for septic shock among adult patients, when compared with norepinephrine. Patients who reached a prespecified dose of either vasopressor were further randomized to receive hydrocortisone or placebo. A proportion of patients in the Vasopressin vs Norepinephrine as Initial Therapy in Septic Shock trial had transcriptomic data generated at baseline using whole blood-derived messenger RNA. We used the publicly avail

SUBMITTER: Wong HR 

PROVIDER: S-EPMC7746624 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature