Neural Generators Underlying Temporal Envelope Processing Show Altered Responses and Hemispheric Asymmetry Across Age.

ABSTRACT: Speech understanding problems are highly prevalent in the aging population, even when hearing sensitivity is clinically normal. These difficulties are attributed to changes in central temporal processing with age and can potentially be captured by age-related changes in neural generators. The aim of this study is to investigate age-related changes in a wide range of neural generators during temporal processing in middle-aged and older persons with normal audiometric thresholds. A minimum-norm imaging technique is employed to reconstruct cortical and subcortical neural generators of temporal processing for different acoustic modulations. The results indicate that for relatively slow modulations (<50 Hz), the response strength of neural sources is higher in older adults than in younger ones,

SUBMITTER: Farahani ED 

PROVIDER: S-EPMC7746817 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature