The Identification of Critical m⁶A RNA Methylation Regulators as Malignant Prognosis Factors in Prostate Adenocarcinoma.

ABSTRACT: RNA methylation accounts for over 60% of all RNA modifications, and N⁶-methyladenosine (m⁶A) is the most common modification on mRNA and lncRNA of human beings. It has been found that m⁶A modification occurs in microRNA, circRNA, rRNA, and tRNA, etc. The m⁶A modification plays an important role in regulating gene expression, and the abnormality of its regulatory mechanism refers to many human diseases, including cancers. Pitifully, as it stands there is a serious lack of knowledge of the extent to which the expression and function of m⁶A RNA methylation can influence prostate cancer (PC). Herein, we systematically analyzed the expression levels of 35 m⁶A RNA methylation regulators mentioned in literatures among prostate aden

SUBMITTER: Xu J 

PROVIDER: S-EPMC7746824 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature