Immunosuppressive agents for rheumatoid arthritis: a systematic review of clinical trials and their current development stage.

ABSTRACT:

Aims

With the arrival of conventional synthetic (csDMARDs), biological (bDMARDS) and then targeted synthetic (tsDMARDs) disease-modifying anti-rheumatic drugs, the therapeutic arsenal against rheumatoid arthritis (RA) has recently expanded. However, there are still some unmet needs for patients who do not achieve remission and continue to worsen despite treatments. Of note, most randomized controlled trials show that, for methotrexate-inadequate responders, only 20% of patients are ACR70 responders. With our better understanding of RA pathogenesis, finding new treatments is a necessary challenge. The objective of our study was to analyse the whole pipeline of immunosuppressive and immunomodulating drugs evaluated in RA and describe their mechanisms of action and stage of clinical d

SUBMITTER: Blaess J 

PROVIDER: S-EPMC7747097 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature