Electromechanical coupling in the hyperpolarization-activated K⁺ channel KAT1.

ABSTRACT: Voltage-gated potassium (K_v) channels coordinate electrical signalling and control cell volume by gating in response to membrane depolarization or hyperpolarization. However, although voltage-sensing domains transduce transmembrane electric field changes by a common mechanism involving the outward or inward translocation of gating charges^1-3, the general determinants of channel gating polarity remain poorly understood⁴. Here we suggest a molecular mechanism for electromechanical coupling and gating polarity in non-domain-swapped K_v channels on the basis of the cryo-electron microscopy structure of KAT1, the hyperpolarization-activated K_v channel from Arabidopsis thaliana. KAT1 displays a depolarized voltage sensor, which interacts with

SUBMITTER: Clark MD 

PROVIDER: S-EPMC7747229 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature