Lung Stereotactic Body Radiation Therapy and Concurrent Immunotherapy: A Multicenter Safety and Toxicity Analysis.

ABSTRACT:

Purpose

Radical treatment of metastases with stereotactic body radiation therapy (SBRT) is commonly implemented in patients receiving concurrent immune checkpoint inhibition (ICI), despite limited safety and toxicity data. The purpose of this study was to evaluate the safety and tolerability of lung SBRT with concurrent ICI.

Methods and materials

Records from a single academic institution were reviewed to identify patients treated with lung SBRT and concurrent (within 30 days) ICI; a contemporaneous cohort receiving lung SBRT alone was included for reference. Treatment-related adverse effects occurring within 30 days (acute) and 180 days (subacute) of SBRT were evaluated.

Results

Our study included 117 patients; 54 received SBRT with concurrent ICI (56 courses, 69 tar

SUBMITTER: Tian S 

PROVIDER: S-EPMC7747230 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature