A biomimetic engineered bone platform for advanced testing of prosthetic implants.

ABSTRACT: Existing methods for testing prosthetic implants suffer from critical limitations, creating an urgent need for new strategies that facilitate research and development of implants with enhanced osseointegration potential. Herein, we describe a novel, biomimetic, human bone platform for advanced testing of implants in vitro, and demonstrate the scientific validity and predictive value of this approach using an assortment of complementary evaluation methods. We anchored titanium (Ti) and stainless steel (SS) implants into biomimetic scaffolds, seeded with human induced mesenchymal stem cells, to recapitulate the osseointegration process in vitro. We show distinct patterns of gene expression, matrix deposition, and mineralization in response to the two materials, with Ti implants ultimately re

SUBMITTER: Sladkova-Faure M 

PROVIDER: S-EPMC7747643 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature