Intratumor Heterogeneity Correlates With Reduced Immune Activity and Worse Survival in Melanoma Patients.

ABSTRACT:

Background

Human malignant melanoma is a highly aggressive, heterogeneous and drug-resistant cancer. Due to a high number of clones, harboring various mutations that affect key pathways, there is an exceptional level of phenotypic variation and intratumor heterogeneity (ITH) in melanoma. This poses a significant challenge to personalized cancer medicine. Hitherto, it remains unclear to what extent the heterogeneity of melanoma affects the immune microenvironment. Herein, we explore the interaction between the tumor heterogeneity and the host immune response in a melanoma cohort utilizing The Cancer Genome Atlas (TCGA).

Methods

Clonal Heterogeneity Analysis Tool (CHAT) was used to estimate intratumor heterogeneity, and immune cell composition was estimated using CIBERSORT. Th

SUBMITTER: Lin Z 

PROVIDER: S-EPMC7747763 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature