Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment.

ABSTRACT:

Introduction

We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression.

Methods

This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression.

Results

A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression.

Conclusions

This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population.

SUBMITTER: Oliveira SG 

PROVIDER: S-EPMC7747812 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature