Folic Acid Supplementation and the Association between Maternal Airborne Particulate Matter Exposure and Preterm Delivery: A National Birth Cohort Study in China.

ABSTRACT:

Background

Potential modification of the association between maternal particulate matter (PM) exposure and preterm delivery (PTD) by folic acid (FA) supplementation has not been studied.

Objective

We examined whether FA supplementation could reduce the risk of PTD associated with maternal exposure to PM in ambient air during pregnancy.

Method

In a cohort study covering 30 of the 31 provinces of mainland China in 2014, 1,229,556 primiparas of Han ethnicity were followed until labor. We collected information on their FA supplementation and pregnancy outcomes and estimated each participant's exposure to PM with diameters of ≤10μm (PM10), 2.5μm (PM2.5), and 1μm (PM1) using satellite remote-sensing based models. Cox proportional hazard regression models were used to examin

SUBMITTER: Li Q 

PROVIDER: S-EPMC7747880 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature