Traumatic stress and the circadian system: neurobiology, timing and treatment of posttraumatic chronodisruption.

ABSTRACT: Background: Humans have an evolutionary need for a well-preserved internal 'clock', adjusted to the 24-hour rotation period of our planet. This intrinsic circadian timing system enables the temporal organization of numerous physiologic processes, from gene expression to behaviour. The human circadian system is tightly and bidirectionally interconnected to the human stress system, as both systems regulate each other's activity along the anticipated diurnal challenges. The understanding of the temporal relationship between stressors and stress responses is critical in the molecular pathophysiology of stress-and trauma-related diseases, such as posttraumatic stress disorder (PTSD). Objectives/Methods: In this narrative review, we present the functional components of the stress a

SUBMITTER: Agorastos A 

PROVIDER: S-EPMC7747941 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature