Ontology highlight
ABSTRACT:
SUBMITTER: Huang JR
PROVIDER: S-EPMC7748110 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frontiers in pharmacology 20201112
Colorectal cancer is one of the most common and lethal cancers in the world. An important causative factor of colorectal cancer is ulcerative colitis. In this study, we investigated the therapeutic effects of piperlongumine (PL) on the dextran sulfate sodium (DSS)-induced acute colitis and azoxymethane (AOM)/DSS-induced colorectal cancer mouse models. Our results showed that PL could inhibit the inflammation of DSS-induced mouse colitis and reduce the number of large neoplasms (diameter >2 mm) o ...[more]