Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and male infertility risk: An updated meta-analysis.

ABSTRACT:

Background

18 previous meta-analyses have been published on the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms with male infertility risk. However, results of the previous meta-analyses were still inconsistent. Moreover, their meta-analyses did not assess false-positive report probabilities except one study. Furthermore, many new studies have been published, and therefore an updated meta-analysis and re-analysis of systematic previous meta-analyses were performed to further explore these issues.

Objectives

To determine the association between MTHFR C677T and A1298C polymorphisms and male infertility risk.

Methods

Crude odds ratios and their 95% confidence intervals were used to assess the association between MTHFR C677T and A1298C polymorph

SUBMITTER: Han LJ 

PROVIDER: S-EPMC7748209 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature