Operations Research Methods for Estimating the Population Size of Neuron Types.

ABSTRACT: Understanding brain computation requires assembling a complete catalog of its architectural components. Although the brain is organized into several anatomical and functional regions, it is ultimately the neurons in every region that are responsible for cognition and behavior. Thus, classifying neuron types throughout the brain and quantifying the population sizes of distinct classes in different regions is a key subject of research in the neuroscience community. The total number of neurons in the brain has been estimated for multiple species, but the definition and population size of each neuron type are still open questions even in common model organisms: the so called "cell census" problem. We propose a methodology that uses operations research principles to estimate the number of neuro

SUBMITTER: Attili SM 

PROVIDER: S-EPMC7748248 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature