FDXR regulates TP73 tumor suppressor via IRP2 to modulate aging and tumor suppression.

ABSTRACT: Ferredoxin reductase (FDXR) is a mitochondrial flavoprotein that initiates electron transport from NADPH to several cytochromes P450 via two electron carriers, ferredoxin 1 (FDX1) and FDX2. FDXR is the sole ferredoxin reductase in humans and plays a critical role in steroidogenesis and biosynthesis of heme and iron-sulfur clusters. However, much less is known about the role of FDXR in cancer. Here, we show that FDXR plays a role in tumorigenesis by modulating expression of the tumor suppressor p73. By using genetically modified mouse models, we recently showed that mice deficient in either Fdxr or Trp73 had a shorter lifespan and were prone to spontaneous tumors as compared with wild-type (WT) mice. Interestingly, compound Trp73 ^+/- ;Fdxr ^+/- mice lived longer and dev

SUBMITTER: Zhang J 

PROVIDER: S-EPMC7748393 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature