Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation.

ABSTRACT: The risk of life-threatening COVID-19 pneumonia increases sharply after 65 years of age, but other epidemiological risk factors, genetic or otherwise, are modest. Various rare monogenic inborn errors of type I interferons (IFNs) underlie critical disease, and neutralizing autoantibodies against type I IFNs account for at least 10% of critical cases.

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC7748410 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature