Assessment of right ventricular sympathetic dysfunction in patients with arrhythmogenic right ventricular cardiomyopathy: An ¹²³I-metaiodobenzylguanidine SPECT/CT study.

ABSTRACT:

Purpose

The purpose of the study was to evaluate a novel approach for the quantification of right ventricular sympathetic dysfunction in patients diagnosed with ARVC/D through state-of-the-art functional SPECT/CT hybrid imaging.

Methods

Sympathetic innervation of the heart was assessed using ¹²³I-MIBG-SPECT/CT in 17 patients diagnosed with ARVC according to the modified task force criteria, and in 10 patients diagnosed with idiopathic ventricular fibrillation (IVF). The ¹²³I-MIBG-uptake in the left (LV) and right ventricle (RV) was evaluated separately based on anatomic information derived from the CT scan, and compared to the uptake in the mediastinum (M).

Results

There was a significant difference in the LV/M ratio between the ARVC/D and the IV

SUBMITTER: Todica A 

PROVIDER: S-EPMC7749057 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature