Glucagon-like peptide-1 receptor expression after myocardial infarction: Imaging study using ⁶⁸Ga-NODAGA-exendin-4 positron emission tomography.

ABSTRACT:

Background

Activation of glucagon-like peptide-1 receptor (GLP-1R) signaling protects against cardiac dysfunction and remodeling after myocardial infarction (MI). The aim of the study was to evaluate ⁶⁸Ga-NODAGA-exendin-4 positron emission tomography (PET) for assessment of GLP-1R expression after MI in rats.

Methods and results

Rats were studied at 3 days, 1 and 12 weeks after permanent coronary ligation or a sham-operation. Rats were injected with ⁶⁸Ga-NODAGA-exendin-4 and scanned with PET and contrast-enhanced computed tomography (CT) followed by digital autoradiography and histology of left ventricle tissue sections. ⁶⁸Ga-NODAGA-exendin-4 PET/CT showed focally increased tracer uptake in the infarcted regions peaking at 3 days and continui

SUBMITTER: Stahle M 

PROVIDER: S-EPMC7749060 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature