Characterization of focused ultrasound-mediated brainstem delivery of intranasally administered agents.

ABSTRACT: Focused ultrasound-mediated intranasal (FUSIN) delivery is a recently proposed technique that bypasses the blood-brain barrier to achieve noninvasive and localized brain drug delivery. The goal of this study was to characterize FUSIN drug delivery outcome in mice with regard to its dependency on several critical experimental factors, including the time interval between IN administration and FUS sonication (T_lag1), the FUS pressure, and the time for sacrificing the mice post-FUS (T_lag2). Wild-type mice were treated by FUSIN delivery of near-infrared fluorescent dye-labeled bovine serum albumin (800CW-BSA, used as a model agent). 800CW-BSA was intranasally administered to the mice in vivo, followed by intravenous injection of microbubbles and FUS sonication at the brain

SUBMITTER: Ye D 

PROVIDER: S-EPMC7749082 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature