A complete rule set for designing symmetry combination materials from protein molecules.

ABSTRACT: Diverse efforts in protein engineering are beginning to produce novel kinds of symmetric self-assembling architectures, from protein cages to extended two-dimensional (2D) and three-dimensional (3D) crystalline arrays. Partial theoretical frameworks for creating symmetric protein materials have been introduced, but no complete system has been articulated. Only a minute fraction of the possible design space has been explored experimentally, in part because that space has not yet been described in theory. Here, in the form of a multiplication table, we lay out a complete rule set for materials that can be created by combining two chiral oligomeric components (e.g., proteins) in precise configurations. A unified system is described for parameterizing and searching the construction space for a

SUBMITTER: Laniado J 

PROVIDER: S-EPMC7749312 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature