Fouling-resistant zwitterionic polymers for complete prevention of postoperative adhesion.

ABSTRACT: Postoperative adhesions are most common issues for almost any types of abdominal and pelvic surgery, leading to adverse consequences. Pharmacological treatments and physical barrier devices are two main approaches to address postoperative adhesions but can only alleviate or reduce adhesions to some extent. There is an urgent need for a reliable approach to completely prevent postoperative adhesions and to significantly improve the clinical outcomes, which, however, is unmet with current technologies. Here we report that by applying a viscous, cream-like yet injectable zwitterionic polymer solution to the traumatized surface, postoperative adhesion was completely and reliably prevented in three clinically relevant but increasingly challenging models in rats. The success rate of full prevent

SUBMITTER: Zhang E 

PROVIDER: S-EPMC7749340 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature