The potential for intramuscular depot medroxyprogesterone acetate as a self-bridging emergency contraceptive.

ABSTRACT:

Objective

To examine the rate of ovulatory disruption when intramuscular depot medroxyprogesterone acetate (DMPA) is administered across graded stages of dominant follicle development.

Study design

We assigned enrolled participants to one of three preassigned dominant follicle size groups: 12-14 mm, 15-17 mm and ≥ 18 mm. We followed dominant follicles via serial transvaginal ultrasound (TVUS) until the follicles reached their assigned size, at which time we administered DMPA. For 5 consecutive days thereafter, we followed the follicles via TVUS to observe follicle rupture and obtained serum luteinizing hormone (LH), estradiol, and progesterone concentrations. In the following 2 weeks, we collected serum progesterone concentrations twice weekly to detect possible ovulatory de

SUBMITTER: Schickler R 

PROVIDER: S-EPMC7749364 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature