Multiomics Characterization of Preterm Birth in Low- and Middle-Income Countries.

ABSTRACT:

Importance

Worldwide, preterm birth (PTB) is the single largest cause of deaths in the perinatal and neonatal period and is associated with increased morbidity in young children. The cause of PTB is multifactorial, and the development of generalizable biological models may enable early detection and guide therapeutic studies.

Objective

To investigate the ability of transcriptomics and proteomics profiling of plasma and metabolomics analysis of urine to identify early biological measurements associated with PTB.

Design, setting, and participants

This diagnostic/prognostic study analyzed plasma and urine samples collected from May 2014 to June 2017 from pregnant women in 5 biorepository cohorts in low- and middle-income countries (LMICs; ie, Matlab, Bangladesh; Lusaka,

SUBMITTER: Jehan F 

PROVIDER: S-EPMC7749442 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature