Role of densin-180 in mouse ventral hippocampal neurons in 24-hr retention of contextual fear conditioning.

ABSTRACT:

Introduction

Densin-180 interacts with postsynaptic molecules including calcium/calmodulin-dependent protein kinase IIα (CaMKIIα) but its function in learning and memory process has been unclear.

Methods

To investigate a role of hippocampal densin-180 in contextual fear conditioning (CFC) learning and memory processes, knockdown (KD) of densin-180 in hippocampal subareas was applied.

Results

First, ventral hippocampal (vHC) densin-180 KD impaired single-trial CFC (stCFC) memory one day later. stCFC caused freezing behaviors to reach the peak about one hour later in both control and KD mice, but then freezing was disappeared at 2 hr postshock in KD mice. Second, stCFC caused an immediate and transient reduction of vHC densin-180 in control mice, which was not observed

SUBMITTER: Kim CH 

PROVIDER: S-EPMC7749528 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature