White matter abnormalities and cognitive function in euthymic patients with bipolar disorder and major depressive disorder.

ABSTRACT:

Objectives

In recent years, a growing number of diffusion tensor imaging (DTI) studies have compared white matter integrity between patients with major depressive disorder (MDD) and bipolar disorder (BD). However, few studies have examined the pathophysiological significance of different degrees of white matter abnormalities between the two disorders. The present study comprehensively assessed white matter integrity among healthy controls (HC) and euthymic patients with MDD and BD using whole-brain tractography and examined associations between white matter integrity and cognitive functioning.

Methods

We performed neurocognitive examinations and DTI with 30 HCs, 30 patients with MDD, and 30 patients with BD. We statistically evaluated white matter integrity and cognitive fun

SUBMITTER: Masuda Y 

PROVIDER: S-EPMC7749556 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature