Brain metabolites in cholinergic and glutamatergic pathways are altered by pancreatic cancer cachexia.

ABSTRACT:

Background

Cachexia is a major cause of morbidity in pancreatic ductal adenocarcinoma (PDAC) patients. Our purpose was to understand the impact of PDAC-induced cachexia on brain metabolism in PDAC xenograft studies, to gain new insights into the causes of cachexia-induced morbidity. Changes in mouse and human plasma metabolites were characterized to identify underlying causes of brain metabolic changes.

Methods

We quantified metabolites, detected with high-resolution ¹ H magnetic resonance spectroscopy, in the brain and plasma of normal mice (n = 10) and mice bearing cachexia (n = 10) or non-cachexia (n = 9) inducing PDAC xenografts as well as in human plasma obtained from normal individuals (n = 24) and from individuals with benign pancreatic disease (n = 20) and

SUBMITTER: Winnard PT 

PROVIDER: S-EPMC7749557 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature