High levels of modified ceramides are a defining feature of murine and human cancer cachexia.

ABSTRACT:

Background

Cancer cachexia (CCx) is a multifactorial energy-wasting syndrome reducing the efficiency of anti-cancer therapies, quality of life, and survival of cancer patients. In the past years, most studies focused on the identification of tumour and host-derived proteins contributing to CCx. However, there is still a lack of studies addressing the changes in bioactive lipids. The aim of this study was to identify specific lipid species as a hallmark of CCx by performing a broad range lipid analysis of plasma from well-established CCx mouse models as well as cachectic and weight stable cancer patients.

Methods

Plasma from non-cachectic (PBS-injected mice, NC26 tumour-bearing mice), pre-cachectic and cachectic mice (C26 and LLC tumour-bearing mice, Apc^Min/+ mutan

SUBMITTER: Morigny P 

PROVIDER: S-EPMC7749558 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature