Lipid-suppressed and tissue-fraction corrected metabolic distributions in human central brain structures using 2D ¹ H magnetic resonance spectroscopic imaging at 7 T.

ABSTRACT:

Introduction

Magnetic resonance spectroscopic imaging (MRSI) has the potential to add a layer of understanding of the neurobiological mechanisms underlying brain diseases, disease progression, and treatment efficacy. Limitations related to metabolite fitting of low signal-to-noise ratios data, signal variations due to partial-volume effects, acquisition and extracranial lipid artifacts, along with clinically relevant aspects such as scan time constraints, are among the challenges associated with in vivo MRSI.

Methods

The aim of this work was to address some of these factors and to develop an acquisition, reconstruction, and postprocessing pipeline to derive lipid-suppressed metabolite values of central brain structures based on free-induction decay measurements made using a

SUBMITTER: Bhogal AA 

PROVIDER: S-EPMC7749561 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature