Neonatal brain connectivity outliers identify over forty percent of IQ outliers at 4 years of age.

ABSTRACT:

Background

Defining reliable brain markers for the prediction of abnormal behavioral outcomes remains an urgent but extremely challenging task in neuroscience research. This is particularly important for infant studies given the most dramatic brain and behavioral growth during infancy.

Methods

In this study, we proposed a novel prediction scheme through abstracting individual newborn's whole-brain functional connectivity pattern to three outlier measures (Triple O) and tested the hypothesis that neonates identified as "brain outliers" based on Triple O were more likely to develop as IQ outliers at 4 years of age. Without need for training with behavioral data, Triple O represents a novel proof-of-concept approach to predict later IQ outcomes based on neonatal brain data.

SUBMITTER: Gao W 

PROVIDER: S-EPMC7749582 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature