Functional connectivity in default mode network correlates with severity of hypoxemia in obstructive sleep apnea.

ABSTRACT:

Introduction

Obstructive sleep apnea (OSA)-associated hypoxemia, sleep fragmentation, and cerebral vascular dysfunction are implicated in cognitive dysfunction. Functional connectivity within default mode network (DMN) is a possible mechanism underlying the cognitive impairment. The aim of this study was to investigate the impact of hypoxemia and sleep fragmentation on functional connectivity and on cognitive performance in patients with OSA.

Methods

Twenty-eight patients with OSA were included (mean age = 58.0 ± 8.5 years). We correlated the functional connectivity in DMN with cognitive performances and further analyzed the relationship of functional connectivity in DMN with hypoxemia severity, as revealed by apnea-hypopnea index (AHI), oxygen desaturation index (ODI), and

SUBMITTER: Chang YT 

PROVIDER: S-EPMC7749584 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature