Associations between brain-derived neurotrophic factor and cognitive impairment in panic disorder.

ABSTRACT:

Introduction

Our study was designed to examine the relationship between Brain-Derived Neurotrophic Factor (BDNF) genotypes (rs6265, Val66Met), BDNF plasma levels, and cognitive impairment in Chinese patients with panic disorder (PD).

Methods

Total 85 patients with PD and 91 healthy controls finally completed all assessments. The severity of panic symptoms and whole anxiety of PD was measured by Panic Disorder Severity Scale-Chinese Version (PDSS-CV) and Hamilton Anxiety Scale (HAMA-14). Montreal Cognitive Assessment (MoCA) and some neurocognitive measures were conducted to evaluate the cognitive performance. All participants were detected for the plasma BDNF levels and BDNF Val66Met polymorphism before assessment and treatment.

Results

No significant differences were

SUBMITTER: Wang W 

PROVIDER: S-EPMC7749616 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature