Identifying functionally relevant candidate genes for inflexible ethanol intake in mice and humans using a guilt-by-association approach.

ABSTRACT: Gene prioritization approaches are useful tools to explore and select candidate genes in transcriptome studies. Knowing the importance of processes such as neuronal activity, intracellular signal transduction, and synapse plasticity to the development and maintenance of compulsive ethanol drinking, the aim of the present study was to explore and identify functional candidate genes associated with these processes in an animal model of inflexible pattern of ethanol intake. To do this, we applied a guilt-by-association approach, using the GUILDify and ToppGene software, in our previously published microarray data from the prefrontal cortex (PFC) and striatum of inflexible drinker mice. We then tested some of the prioritized genes that showed a tissue-specific pattern in postmortem brain tissu

SUBMITTER: Martins de Carvalho L 

PROVIDER: S-EPMC7749619 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature