Satellite cell self-renewal in endurance exercise is mediated by inhibition of mitochondrial oxygen consumption.

ABSTRACT:

Background

Skeletal muscle stem cells (satellite cells) are well known to participate in regeneration and maintenance of the tissue over time. Studies have shown increases in the number of satellite cells after exercise, but their functional role in endurance training remains unexplored.

Methods

Young adult mice were submitted to endurance exercise training and the function, differentiation, and metabolic characteristics of satellite cells were investigated in vivo and in vitro.

Results

We found that injured muscles from endurance-exercised mice display improved regenerative capacity, demonstrated through higher densities of newly formed myofibres compared with controls (evidenced by an increase in embryonic myosin heavy chain expression), as well as lower inflammatio

SUBMITTER: Abreu P 

PROVIDER: S-EPMC7749620 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature