Characterization of cachexia in the human fibrosarcoma HT-1080 mouse tumour model.

ABSTRACT:

Background

Cancer cachexia is a complex metabolic disease with unmet medical need. Although many rodent models are available, none are identical to the human disease. Therefore, the development of new preclinical models that simulate some of the physiological, biochemical, and clinical characteristics of the human disease is valuable. The HT-1080 human fibrosarcoma tumour cell line was reported to induce cachexia in mice. Therefore, the purpose of this work was to determine how well the HT-1080 tumour model could recapitulate human cachexia and to examine its technical performance. Furthermore, the efficacy of ghrelin receptor activation via anamorelin treatment was evaluated, because it is one of few clinically validated mechanisms.

Methods

Female severe combined immunodefi

SUBMITTER: Bernardo B 

PROVIDER: S-EPMC7749621 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature