Differential effects of right and left heart failure on skeletal muscle in rats.

ABSTRACT:

Background

Exercise intolerance is a cardinal symptom in right (RV) and left ventricular (LV) failure. The underlying skeletal muscle contributes to increased morbidity in patients. Here, we compared skeletal muscle sarcopenia in a novel two-stage model of RV failure to an established model of LV failure.

Methods

Pulmonary artery banding (PAB) or aortic banding (AOB) was performed in weanling rats, inducing a transition from compensated cardiac hypertrophy (after 7 weeks) to heart failure (after 22-26 weeks). Cardiac function was characterized by echocardiography. Skeletal muscle catabolic/anabolic balance and energy metabolism were analysed by histological and biochemical methods, real-time PCR, and western blot.

Results

Two clearly distinguishable stages of left or

SUBMITTER: Knapp F 

PROVIDER: S-EPMC7749622 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature