Urinary MMP-9/UCr association with albumin concentration and albumin-creatinine-ratio in Mexican patients with type 2 diabetes mellitus.

ABSTRACT:

Background

Chronic kidney disease is one of the most common complications of type 2 diabetes mellitus (T2DM), causing an increased risk of cardiovascular morbidity and mortality. Matrix metalloproteinase (MMP) activity has been proposed as useful biomarker for diabetic renal and vascular complications.

Methods

A cross-sectional study was conducted among T2DM patients who attended a public secondary hospital in Mexico. We performed clinical, biochemical, and microbiological assessments, as well chronic kidney disease diagnosis according to the KDIGO guideline. Urinary MMP-9 was quantified by ELISA and adjusted using urinary creatinine (UCr).

Results

A total of 111 patients were included. Most participants were women (66%). Mean age was 61 ± 10 years and median T2DM dur

SUBMITTER: Arcos-Sacramento VG 

PROVIDER: S-EPMC7749659 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature