Association of liver abnormalities with in-hospital mortality in patients with COVID-19.

ABSTRACT:

Background & aims

The evolution and clinical significance of abnormal liver chemistries and the impact of hepatitis B infection on outcome in patients with COVID-19 is not well characterized. This study aimed to explore these issues.

Methods

This large retrospective cohort study included 2,073 patients with coronavirus disease 2019 (COVID-19) and definite outcomes in Wuhan, China. Longitudinal liver function tests were conducted, with associated factors and risk of death determined by multivariate regression analyses. A prognostic nomogram was formulated to predict the survival of patients with COVID-19. The characteristics of liver abnormalities and outcomes of patients with COVID-19, with and without hepatitis B, were compared after 1:3 propensity score matching.

Result

SUBMITTER: Ding ZY 

PROVIDER: S-EPMC7749734 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature