Acute neuroimmune stimulation impairs verbal memory in adults: A PET brain imaging study.

ABSTRACT: Psychiatric and neurologic disorders are often characterized by both neuroinflammation and cognitive dysfunction. To date, however, the relationship between neuroinflammation and cognitive dysfunction remains understudied in humans. Preclinical research indicates that experimental induction of neuroinflammation reliably impairs memory processes. In this paradigm development study, we translated those robust preclinical findings to humans using positron emission tomography (PET) imaging with [¹¹C]PBR28, a marker of microglia, and lipopolysaccharide (LPS), a potent neuroimmune stimulus. In a sample of 18 healthy adults, we extended our previous findings that LPS administration increased whole-brain [¹¹C]PBR28 availability by 31-50%, demonstrating a robust neuroimmune re

SUBMITTER: Woodcock EA 

PROVIDER: S-EPMC7749814 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature