A systematic review assessing the under-representation of elderly adults in COVID-19 trials.

ABSTRACT:

Background

Coronavirus disease (COVID-19) has caused a pandemic threatening millions of people worldwide. Yet studies specifically assessing the geriatric population are scarce. We aimed to examine the participation of elderly patients in therapeutic or prophylactic trials on COVID-19.

Methods

In this review, randomized controlled trials (RCTs; n = 12) comparing therapeutic or prophylactic interventions registered on preprint repositories and/or published since December 2019 were analyzed. We searched in PubMed, leading journals websites, and preprint repositories for RCTs and large observational studies. We aimed to describe the age of included patients, the presence of an upper age limit and of adjusted analyses on age, any exclusion criteria that could limit participation

SUBMITTER: Prendki V 

PROVIDER: S-EPMC7749979 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature