Blunted prefrontal signature of proactive inhibitory control in cocaine use disorder.

ABSTRACT:

Background

Impulsivity is an established risk factor for substance use disorder (SUD). Integral to SUD recovery is proactive control (leveraging information about a potential need for behavioral restraint to marshal increased cognitive resources toward inhibition) when cues for drug use are unavoidable. However, proactive control is little studied in SUD, and is merely inferred from post-error performance adjustments.

Methods

We probed covert neurocircuit signatures of proactive control in persons with SUD, as well as the moderating effects of incentives for successfully exerting proactive control. We administered a Monetary Incentive Stop Task (MIST) during functional magnetic resonance imaging of adults with cocaine use disorder (CUD; n = 21) and healthy controls (n = 21).

SUBMITTER: Nigam KB 

PROVIDER: S-EPMC7750200 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature