Remifentanil-food choice follows predictions of relative subjective value.

ABSTRACT:

Background

Preclinical studies into drug vs. nondrug choice have emerged to better model and investigate the neurobehavioral mechanisms underlying drug preference. Current literature has suggested that drugs of abuse have inherently low value, thus promoting food preference. Herein, we examined remifentanil vs. food choice to test both the relative value hypothesis and the 'direct effects' (pharmacological effects of drugs on alternative reinforcers) hypothesis of opioid preference.

Methods

Adult male rats were trained under two choice procedures (controlled vs. uncontrolled reinforcer frequency) for remifentanil vs. food choice. Furthermore, a series of procedural manipulations known to affect drug reinforcement were tested under both choice procedures. Using remifentanil s

SUBMITTER: Chow JJ 

PROVIDER: S-EPMC7750270 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature