Quantum mechanical NMR full spin analysis in pharmaceutical identity testing and quality control.

ABSTRACT: Issues related to pharmaceutical quality are arising at an alarming rate. Pharmaceutical quality concerns both the Active Pharmaceutical Ingredients (APIs) and the Finished Drug Product/ Formulation. Recently, there has been a significant increase in the number of reports of harmful impurities in marketed drug formulations. Impurities range from solvents, reactants, adulterants, and catalysts to synthetic byproducts. Quality concerns in commercial preparations may also arise due to shelf life stability. Furthermore, a number of falsified and substandard drug cases have been reported. Most of the techniques which are currently in place can, at best, detect the impurities, but cannot identify them unless they are already known and can be compared to a standard. On the other hand, ¹

SUBMITTER: Achanta PS 

PROVIDER: S-EPMC7750297 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature