Both HIV and Tat expression decrease prepulse inhibition with further impairment by methamphetamine.

ABSTRACT: HIV infection and methamphetamine (METH) use are highly comorbid and represent a significant public health problem. Both conditions are known to negatively impact a variety of brain functions. One brain function that may be affected by HIV and METH use is sensorimotor gating, an automatic, pre-conscious filtering of sensory information that is thought to contribute to higher order cognitive processes. Sensorimotor gating is often measured using prepulse inhibition (PPI), a paradigm that can be conducted in both humans and animals, thereby enabling cross-species translational studies. While previous studies suggest HIV and METH may individually impair PPI, little research has been conducted on the effects of combined HIV and METH on PPI. The goal of this cross-species study was to determine

SUBMITTER: Walter TJ 

PROVIDER: S-EPMC7750302 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature