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Role of the Intestinal Epithelium and Its Interaction With the Microbiota in Food Allergy.


ABSTRACT: The intestinal epithelial tract forms a dynamic lining of the digestive system consisting of a range of epithelial cell sub-types with diverse functions fulfilling specific niches. The intestinal epithelium is more than just a physical barrier regulating nutrient uptake, rather it plays a critical role in homeostasis through its intrinsic innate immune function, pivotal regulation of antigen sensitization, and a bi-directional interplay with the microbiota that evolves with age. In this review we will discuss these functions of the epithelium in the context of food allergy.

SUBMITTER: Ali A 

PROVIDER: S-EPMC7750388 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Role of the Intestinal Epithelium and Its Interaction With the Microbiota in Food Allergy.

Ali Ayesha A   Tan HuiYing H   Kaiko Gerard E GE  

Frontiers in immunology 20201207


The intestinal epithelial tract forms a dynamic lining of the digestive system consisting of a range of epithelial cell sub-types with diverse functions fulfilling specific niches. The intestinal epithelium is more than just a physical barrier regulating nutrient uptake, rather it plays a critical role in homeostasis through its intrinsic innate immune function, pivotal regulation of antigen sensitization, and a bi-directional interplay with the microbiota that evolves with age. In this review w  ...[more]

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