Liver kinase B1 inhibits smooth muscle calcification via high mobility group box 1.

ABSTRACT: Vascular calcification is a common pathological feature of atherosclerosis, chronic kidney disease, vascular injury, and aging. Liver kinase B1 (LKB1) plays pivotal roles in cellular processes such as apoptosis, metabolism, and cell cycle regulation. In addition, growing evidence has indicated that LKB1 functions as a tumor suppressor gene. However, its role in vascular calcification has not been reported. LKB1^flox/flox mice were hybridized with SM22-CreER^T2 transgenic mice and adult mice received tamoxifen to obtain smooth muscle-specific LKB1-knockout (LKB1^SMKO) mice. LKB1 expression was decreased under calcifying conditions, and LKB1 overexpression had a protective effect on vascular calcification. However, high mobility group box 1 (HMGB1) overexpressio

SUBMITTER: Zhang T 

PROVIDER: S-EPMC7750422 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature